Friday, November 8, 2013

NASA's Hubble sees asteroid spouting 6 comet-like tails

NASA's Hubble sees asteroid spouting 6 comet-like tails


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Contact: Cheryl Gundy
gundy@stsci.edu
410-338-4707
NASA/Goddard Space Flight Center






Astronomers viewing our solar system's asteroid belt with NASA's Hubble Space Telescope have seen for the first time an asteroid with six comet-like tails of dust radiating from it like spokes on a wheel.


Unlike all other known asteroids, which appear simply as tiny points of light, this asteroid, designated P/2013 P5, resembles a rotating lawn sprinkler. Astronomers are puzzled over the asteroid's unusual appearance.


"We were literally dumbfounded when we saw it," said lead investigator David Jewitt of the University of California at Los Angeles. "Even more amazing, its tail structures change dramatically in just 13 days as it belches out dust. That also caught us by surprise. It's hard to believe we're looking at an asteroid."


Jewitt leads a team whose research paper appears online in the Nov. 7 issue of the Astrophysical Journal Letters.


P/2013 P5 has been ejecting dust periodically for at least five months. Astronomers believe it is possible the asteroid's rotation rate increased to the point where its surface started flying apart. They do not believe the tails are the result of an impact with another asteroid because they have not seen a large quantity of dust blasted into space all at once.


Scientists using the Pan-STARRS survey telescope in Hawaii announced their discovery of the asteroid Aug. 27. P/2013 P5 appeared as an unusually fuzzy-looking object. The multiple tails were discovered when Hubble was used to take a more detailed image Sept. 10.


When Hubble looked at the asteroid again Sept. 23, its appearance had totally changed. It looked as if the entire structure had swung around.


"We were completely knocked out," Jewitt said.


Careful modeling by team member Jessica Agarwal of the Max Planck Institute for Solar System Research in Lindau, Germany, showed that the tails could have been formed by a series of impulsive dust-ejection events. She calculated that dust-ejection events occurred April 15, July 18, July 24, Aug. 8, Aug. 26 and Sept. 4. Radiation pressure from the sun stretched the dust into streamers.


Radiation pressure could have spun P/2013 P5 up. Jewitt said the spin rate could have increased enough that the asteroid's weak gravity no longer could hold it together. If that happened, dust could slide toward the asteroid's equator, shatter and fall off, and drift into space to make a tail. So far, only about 100 to 1,000 tons of dust, a small fraction of the P/2013 P5's main mass, has been lost. The asteroid's nucleus, which measures 1,400 feet wide, is thousands of times more massive than the observed amount of ejected dust.


Astronomers will continue observing P/2013 P5 to see whether the dust leaves the asteroid in the equatorial plane. If it does, this would be strong evidence for a rotational breakup. Astronomers will also try to measure the asteroid's true spin rate.


Jewitt's interpretation implies that rotational breakup must be a common phenomenon in the asteroid belt; it may even be the main way small asteroids die.


"In astronomy, where you find one, you eventually find a whole bunch more," Jewitt said. "This is just an amazing object to us, and almost certainly the first of many more to come."


Jewitt said it appears P/2013 P5 is a fragment of a larger asteroid that broke apart in a collision roughly 200 million years ago. There are many collision fragments in orbits similar to P/2013 P5's. Meteorites from these bodies show evidence of having been heated to as much as 1,500 degrees Fahrenheit. This means the asteroid likely is composed of metamorphic rocks and does not hold any ice as a comet does.

###


For images and more information about P/2013 P5, visit:


http://hubblesite.org/news/2013/52


For more information about NASA's Hubble Space Telescope, visit:


http://www.nasa.gov/hubble




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NASA's Hubble sees asteroid spouting 6 comet-like tails


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7-Nov-2013



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Contact: Cheryl Gundy
gundy@stsci.edu
410-338-4707
NASA/Goddard Space Flight Center






Astronomers viewing our solar system's asteroid belt with NASA's Hubble Space Telescope have seen for the first time an asteroid with six comet-like tails of dust radiating from it like spokes on a wheel.


Unlike all other known asteroids, which appear simply as tiny points of light, this asteroid, designated P/2013 P5, resembles a rotating lawn sprinkler. Astronomers are puzzled over the asteroid's unusual appearance.


"We were literally dumbfounded when we saw it," said lead investigator David Jewitt of the University of California at Los Angeles. "Even more amazing, its tail structures change dramatically in just 13 days as it belches out dust. That also caught us by surprise. It's hard to believe we're looking at an asteroid."


Jewitt leads a team whose research paper appears online in the Nov. 7 issue of the Astrophysical Journal Letters.


P/2013 P5 has been ejecting dust periodically for at least five months. Astronomers believe it is possible the asteroid's rotation rate increased to the point where its surface started flying apart. They do not believe the tails are the result of an impact with another asteroid because they have not seen a large quantity of dust blasted into space all at once.


Scientists using the Pan-STARRS survey telescope in Hawaii announced their discovery of the asteroid Aug. 27. P/2013 P5 appeared as an unusually fuzzy-looking object. The multiple tails were discovered when Hubble was used to take a more detailed image Sept. 10.


When Hubble looked at the asteroid again Sept. 23, its appearance had totally changed. It looked as if the entire structure had swung around.


"We were completely knocked out," Jewitt said.


Careful modeling by team member Jessica Agarwal of the Max Planck Institute for Solar System Research in Lindau, Germany, showed that the tails could have been formed by a series of impulsive dust-ejection events. She calculated that dust-ejection events occurred April 15, July 18, July 24, Aug. 8, Aug. 26 and Sept. 4. Radiation pressure from the sun stretched the dust into streamers.


Radiation pressure could have spun P/2013 P5 up. Jewitt said the spin rate could have increased enough that the asteroid's weak gravity no longer could hold it together. If that happened, dust could slide toward the asteroid's equator, shatter and fall off, and drift into space to make a tail. So far, only about 100 to 1,000 tons of dust, a small fraction of the P/2013 P5's main mass, has been lost. The asteroid's nucleus, which measures 1,400 feet wide, is thousands of times more massive than the observed amount of ejected dust.


Astronomers will continue observing P/2013 P5 to see whether the dust leaves the asteroid in the equatorial plane. If it does, this would be strong evidence for a rotational breakup. Astronomers will also try to measure the asteroid's true spin rate.


Jewitt's interpretation implies that rotational breakup must be a common phenomenon in the asteroid belt; it may even be the main way small asteroids die.


"In astronomy, where you find one, you eventually find a whole bunch more," Jewitt said. "This is just an amazing object to us, and almost certainly the first of many more to come."


Jewitt said it appears P/2013 P5 is a fragment of a larger asteroid that broke apart in a collision roughly 200 million years ago. There are many collision fragments in orbits similar to P/2013 P5's. Meteorites from these bodies show evidence of having been heated to as much as 1,500 degrees Fahrenheit. This means the asteroid likely is composed of metamorphic rocks and does not hold any ice as a comet does.

###


For images and more information about P/2013 P5, visit:


http://hubblesite.org/news/2013/52


For more information about NASA's Hubble Space Telescope, visit:


http://www.nasa.gov/hubble




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Source: http://www.eurekalert.org/pub_releases/2013-11/nsfc-nhs110713.php
Category: chris brown   randall cobb   act   sports illustrated   khan academy  

Not good enough: Math, reading scores up slightly

Charts show percentages of students performing at or above proficiency in math and reading; 2c x 5 inches; 96.3 mm x 127 mm;







Charts show percentages of students performing at or above proficiency in math and reading; 2c x 5 inches; 96.3 mm x 127 mm;







Education Secretary Arne Duncan, left, stands with Washington Mayor Vincent Gray, as he speaks to reporters during a visit to Malcolm X Elementary School in Washington, Thursday, Nov. 7, 2013. Duncan announced that today's fourth and eighth graders are doing better than their predecessors in math and reading. Today’s fourth and eighth graders are doing better than their predecessors in math and reading, but despite record high scores it’s too soon to start celebrating. The vast majority of students still are not demonstrating solid academic achievement in either subject, according to the Nation’s Report Card, released Thursday. (AP Photo/Susan Walsh)







Education Secretary Arne Duncan arrives for a visit to Malcolm X Elementary School in Washington, Thursday, Nov. 7, 2013. Duncan announced that today's fourth and eighth graders are doing better than their predecessors in math and reading. Today’s fourth and eighth graders are doing better than their predecessors in math and reading, but despite record high scores it’s too soon to start celebrating. The vast majority of students still are not demonstrating solid academic achievement in either subject, according to the Nation’s Report Card, released Thursday (AP Photo/Susan Walsh)







(AP) — Sometimes the best isn't good enough: Most American fourth- and eighth-graders still lack basic skills in math and reading despite record high scores on a national exam.

Yes, today's students are doing better than those who came before them. But the improvements have come at a snail's pace.

The 2013 Nation's Report Card released Thursday finds that the vast majority of the students still are not demonstrating solid academic performance in either math or reading. Stubborn gaps persist between the performances of white children and their Hispanic and African-American counterparts, who scored much lower.

Overall, just 42 percent of fourth-graders and 35 percent of eighth-graders scored at or above the proficient level in math. In reading, 35 percent of fourth graders and 36 percent of eighth graders hit that mark.

Still, as state and federal policies evolve in the post-No Child Left Behind era, the nation's school kids are doing better today on the test than they did in the early 1990s, when such tracking started, with more improvement in math than in reading. Students of all races have shown improvement over the years.

The results come from the National Assessment of Educational Progress, or NAEP, which is given every two years to a sample of fourth- and eighth-graders.

This year's results, compared to results in 2011, show average incremental gains of about one or two points on a 500-point scale in math and reading in both grades, although the one-point gain in fourth grade reading was not considered statistically significant.

"Every two years, the gains tend to be small, but over the long run, they stack up," said Jack Buckley, commissioner of the Education Department's National Center for Education Statistics.

Buckley said he was "heartened" by some of the results, "but there are also some areas where I'd hoped to see improvement where we didn't."

Today, President W. Bush's landmark education law No Child Left Behind, which sought to close achievement gaps among racial groups and have every student doing math and reading at grade level by 2014, has essentially been dismantled.

After Congress failed to update the law before it was due for renewal in 2007, President Barack Obama allowed states to get waivers from it if they showed they have their own plans to prepare students. Most states took him up on the offer.

Meanwhile, a majority of states are rolling out Common Core State Standards with the goal of better preparing the nation's students for college or a job. The states-led standards establish benchmarks for reading and math and replace goals that varied widely from state.

Academic scholars have long debated what effects the law and other state-led reforms have had on test scores.

This year, Tennessee and the District of Columbia, which have both launched high-profile efforts to strengthen education by improving teacher evaluations and by other measures, showed across-the-board growth on the test compared to 2011, likely stoking more debate. Only the Defense Department schools also saw gains in both grade levels and subjects.

In Hawaii, which has also seen a concentrated effort to improve teaching quality, scores also increased with the exception of fourth grade reading. In Iowa and Washington state, scores increased except in 8th-grade math.

Specifically pointing to Tennessee, Hawaii and D.C., Education Secretary Arne Duncan said on a conference call with reporters that many of the changes seen in these states were "very, very difficult and courageous" and appear to have had an impact.

Chris Minnich, executive director of the Council of Chief State School Officers, said the biggest problem revealed in the results is the large gap that exists between the performances of students of different races.

There was a 26-point gap, for example, between how white and African American 4th graders performed on the math section. In eighth grade reading, white students outperformed Hispanic students by 21 points.

"We still have a situation where you have kids that are left behind. They aren't given the same instruction. They aren't given the same expectations as other kids," Minnich said. He said it's time for "doubling down and making sure the gaps get smaller."

Duncan said too many African-American and Hispanic children start kindergarten a year or two behind and that early childhood programs are key to leveling the playing field. Duncan and Obama have lobbied for congressional passage of a preschool-for-all program.

This test specifically looked at the performance of American children, but the results from other recent assessments and studies have shown American children and adults scoring below peers in many other countries.

The exam was given this year to about 377,000 fourth graders and 342,000 eighth graders in public and private schools. However, state-specific numbers are only from public schools.

In math, students were asked to answer questions about topics such as geometry, algebra and measurement. In reading, students were told to read passages and recall details or interpret them.

Among the other results:

—More boys than girls scored at or above the proficient level for both grades in math. In reading, more girls than boys scored at or above that mark.

—Twenty-five out of the 52 states or jurisdictions measured had a higher average score in 2013 than in 2011 in at least one subject and grade.

—Five states had a lower score than two years ago in at least one subject and grade: Massachusetts, Montana, North Dakota, Oklahoma, and South Dakota.

—Hispanic students were the only racial or ethnic group that saw improvements in math scores in both fourth and eighth grades; Asian/Pacific Islanders students had the highest percentage of students performing at or above the proficient level in both math and reading.

_____

Online: http://nationsreportcard.gov/reading_math_2013

___

Kimberly Hefling can be followed at http://twitter.com/khefling

Associated PressSource: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-11-07-Nation's%20Report%20Card/id-18ddb4dc88ab4d2a98695abc6c097b10
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Here's what Google's mystery barge is going to look like

What's 50-feet tall, 250-feet long and outfitted with decorative "fish fin" sails? Google's so-called mystery barge, apparently. Mum's still the word in Mountain View, but at the Port of San Francisco, details about the floating technology scow are starting to emerge. Documents obtained by the San ...


Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/IN1dJJx4W3g/
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"Star Wars: Episode VII" Gets An Official Release Date


We know when the new "Star Wars" movie will hit theaters; more news to hit soon?


By Alex Zalben








Source:
http://www.mtv.com/news/articles/1717064/star-wars-episode-VII-release-date.jhtml

Category: Bill De Blasio   WWE   Jamie Dornan   emmys   tesla model s  

New video emerges of ranting Toronto mayor

Toronto Mayor Rob Ford makes a statement to the media outside his office at Toronto's city hall after the release of a video on Thursday Nov. 7, 2013. A new video surfaced showing Ford in a rage, using threatening words including "kill" and "murder." Ford said he was “extremely, extremely inebriated" in the video, which appeared Thursday on the Toronto Star’s website. The context of the video is unknown and it's unclear who the target of Ford's wrath is. (AP Photo/The Canadian Press, Chris Young)







Toronto Mayor Rob Ford makes a statement to the media outside his office at Toronto's city hall after the release of a video on Thursday Nov. 7, 2013. A new video surfaced showing Ford in a rage, using threatening words including "kill" and "murder." Ford said he was “extremely, extremely inebriated" in the video, which appeared Thursday on the Toronto Star’s website. The context of the video is unknown and it's unclear who the target of Ford's wrath is. (AP Photo/The Canadian Press, Chris Young)







Toronto Mayor Rob Ford makes a statement to the media outside his office at Toronto's city hall after the release of a video on Thursday Nov. 7, 2013. A new video surfaced showing Ford in a rage, using threatening words including "kill" and "murder." Ford said he was “extremely, extremely inebriated" in the video, which appeared Thursday on the Toronto Star’s website. The context of the video is unknown and it's unclear who the target of Ford's wrath is. (AP Photo/The Canadian Press, Chris Young)







Toronto Mayor Rob Ford makes a statement to the media outside his office at Toronto's city hall after the release of a video on Thursday Nov. 7, 2013. A new video surfaced showing Ford in a rage, using threatening words including "kill" and "murder." Ford said he was “extremely, extremely inebriated" in the video, which appeared Thursday on the Toronto Star’s website. The context of the video is unknown and it's unclear who the target of Ford's wrath is. (AP Photo/The Canadian Press, Chris Young)







Toronto Mayor Rob Ford talks to a staff member at city hall Wednesday, Nov. 6, 2013 in Toronty. City councilors called on the deputy mayor to "orchestrate a dignified" departure for Ford, who was greeted by angry protesters on his first day of work after acknowledging he smoked crack. Ford took a back stairway to his office to avoid a crush of media and protestors. (AP Photo/The Canadian Press, Chris Young)







Toronto Mayor Rob Ford leaves Toronto's city hall Wednesday, Nov. 6, 2013 in Toronto. City councilors called on the deputy mayor to "orchestrate a dignified" departure for Ford, who was greeted by angry protesters on his first day of work after acknowledging he smoked crack. Ford took a back stairway to his office to avoid a crush of media and protestors. (AP Photo/The Canadian Press, Chris Young)







TORONTO (AP) — A new video that surfaced Thursday shows Toronto Mayor Rob Ford in a rambling rage, using threatening words including "kill" and "murder," as the saga that has gripped Canadians for months took yet another twist.

The mayor told reporters moments after the video was posted online that he was "extremely, extremely inebriated" in it and "embarrassed" by it. The context of the video is unknown and it's unclear who the target of Ford's wrath is. The video, which appeared at length on the Toronto Star's website and in clips on the Toronto Sun's website, prompted another round of calls for Ford to step down.

It's been a whirlwind of a week for Ford, who on Tuesday admitted to smoking crack in a "drunken stupor" about a year ago. Police said last week they had obtained a different, long-sought video that shows Ford smoking a crack pipe.

Police obtained that video in the course of a massive drug investigation into the mayor's friend and occasional driver.

Despite immense pressure from allies and critics, the mayor of North America's fourth largest city has refused to resign or take a leave of absence.

Ford said Thursday he made mistakes and "all I can do is reassure the people. I don't know what to say."

"When you are in that state ... I hope none of you have ever or will ever be in that state," Ford said.

"It's extremely embarrassing. The whole world is going to see it."

In the new video, a visibly agitated Ford paces around, waves his arms and rolls up his sleeves as he says he'll "make sure" the unknown person is dead.

Ford tells another person in the room, possibly the man filming the video, that he wants to "kill" someone in an expletive-laced rant. "Cause I'm going to kill that (expletive) guy," Ford says. "No holds barred brother. He dies or I die."

At one point he says "My brothers are, don't tell me we're liars, thieves, birds?" and then later refers to "80-year-old birds."

The Toronto Star that it purchased the video from "a source who filmed it from someone else's computer" and that "the person with the computer was there in the room."

City Councilor James Pasternak urged Ford to make a "dignified exit."

"The video is very disturbing," he said. "It's very upsetting, it's very sad."

City Councilor Giorgio Mammoliti, a Ford ally, urged the mayor to enter rehab and said in a statement he fears "that if the mayor does not get help now he will succumb to health issues related to addiction."

Ford lawyer Dennis Morris told The Associated Press the context of the video "is skeletal."

"What we have to do is find out when it was taken," he said. "Was it taken eight, 10 months ago or a short time ago? I'm going to try to find that out too. Maybe the Toronto Star knows better."

Asked if Ford told him about the tape, Morris said: "I can't comment, but I don't think we really know."

Earlier Thursday, Morris said he was in talks with the police for Ford to view the video that shows the mayor smoking crack, as city councilors stepped up their efforts to force him from office.

The mayor's travails were taking their toll on his supporters. Canada's finance minister became emotional when asked about Ford, a longtime friend.

Police are seeking to question Ford. Morris previously said Ford would be willing to go view the tape but would not answer questions.

Police have not charged Ford, saying the video didn't provide enough evidence against him. A police spokesman declined to comment.

Municipal law makes no provision for the mayor's forced removal from office unless he's convicted and jailed for a criminal offence.

City Councilor Denzil Minnan-Wong, a member of Ford's executive committee, said Thursday he plans to amend a motion he has filed that would ask Ford to take a leave of absence. The amendment takes the unprecedented step of asking the province of Ontario to pass legislation to remove the mayor if he does not agree to take a leave of absence. The measure could be voted on next Wednesday.

The province, however, has no plans to step in and amend the law to allow Ford to be forced from office, Ontario Municipal Affairs Minister Linda Jeffrey reaffirmed Thursday.

Premier Kathleen Wynne has said she's concerned that Ford's personal issues were making it difficult for the city to carry on normally. But she said it was up to police, the courts or the mayor to take action.

Ford acknowledged a drinking problem for the first time Sunday, saying on his radio show that he was "hammered" in public at a street festival in August and "out of control" drunk, carrying a half empty bottle of brandy around city hall after St. Patrick's Day last year. He then made his stunning confession to reporters Tuesday that he had smoked crack while drunk.

The mayor has called on police to release the tape, but police said they are prohibited from doing so because it is evidence before the courts. Police said the video will come out when Ford associate Alexander Lisi goes to trial on drug and extortion charges.

Toronto Police Chief Bill Blair has also said police have a second tape, but he has declined to discuss what's on it. Police spokesman Mark Pugash told the AP the video released Thursday is not the tape Blair talked about.

The allegations about Ford smoking crack first emerged earlier this year when reporters from the Toronto Star and the U.S. website Gawker separately said they saw that video, but they did not obtain a copy.

___

Follow Rob Gillies on Twitter at —http://twitter.com/rgilliescanada

Associated PressSource: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-11-07-Canada-Toronto%20Mayor/id-fc26f8666e154cd2b060901a752a0438
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Thursday, November 7, 2013

The Economist honors cancer immunotherapy pioneer James Allison

The Economist honors cancer immunotherapy pioneer James Allison


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Contact: Scott Merville
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University of Texas M. D. Anderson Cancer Center



2013 Innovation Award for bioscience goes to MD Anderson scientist



HOUSTON For basic science research that opened a completely new approach for treating cancer, The Economist has named James Allison, Ph.D., professor and chair of Immunology at The University of Texas MD Anderson Cancer Center, as its 2013 Innovations Award winner in Bioscience.


Allison identified an immune checkpoint molecule that turns off T cells white blood cells that are the attack dogs of the immune system before they can mount a successful response to tumors that they are primed to destroy.


An antibody that blocks that immune checkpoint molecule, unleashing a T cell attack, became the first drug to ever extend survival for patients with late-stage melanoma. The U.S. Food and Drug Administration approved ipilumumab (Yervoy) for treatment of metastatic melanoma in 2011.


"The approval of ipilimumab in 2011 represents the culmination of years of research by Dr Allison into tumor immunotherapy," said Tom Standage, Digital Editor at The Economist and chairman of the panel of 30 judges. "We are delighted to recognize his pioneering achievement in the fight against cancer."


The Economist is a 170-year-old weekly news publication based in London with a circulation of 4.5 million worldwide. Its Innovation Awards recognize significant contributions in eight fields: Bioscience, Computing and Telecommunications, Consumer Products, Energy and Environment, Process and Services, Social and Economic, No Boundaries and Corporate.


"I'm honored to receive this award, which recognizes the increasing importance of immune therapy in the treatment of cancer due to the efforts of many scientists, clinicians and patients willing to participate in clinical trials," Allison said.


The adaptive immune system routinely identifies, destroys and remembers infections and abnormal cells. Yet cancer cells evade or suppress immune attack, largely frustrating efforts to develop vaccines and other immune therapies against tumors.


Drug treats immune system, not specific tumor


"Immune checkpoint blockade treats the immune system, not the tumor, so we expect this approach to work across many types of cancer," Allison said. In addition to melanoma, ipilumumab has been effective in clinical trials against prostate, kidney, lung and ovarian cancers.


Allison's basic science research on T cell biology uncovered the receptor on these cells used to recognize and bind to antigens abnormalities that mark defective cells or viruses and bacteria for attack.


He also found that T cells require a second molecular signal to launch a response after they've bound to an antigen. And he identified a molecule called CTLA-4 that acts as an off switch to inhibit activated T cells from attacking.


This led to development of ipilumumab to block CTLA-4. In clinical trials against stage 4 melanoma, the drug extinguished the disease in 20 percent of patients for up to 12 years and counting.


Since arriving at MD Anderson in November 2012, Allison founded and directs an immunotherapy platform to cultivate, support and test new development of immunology-based drugs and combinations. MD Anderson's Moon Shots program, designed to accelerate the conversion of scientific discoveries into clinical advances that reduce cancer deaths, taps the expertise of the immunotherapy platform.


Allison earned his doctorate from The University of Texas at Austin in 1978, joining MD Anderson's faculty after his postdoctoral fellowship. He left MD Anderson for the University of California, Berkeley and later moved to Memorial Sloan-Kettering Cancer Center in New York.


He is a member of the National Academy of Sciences, the Institute of Medicine of the National Academies and has won many honors for biomedical research, including the first AACR-CRI Lloyd J. Old Award in Cancer Immunology at the annual meeting of the American Association for Cancer Research in April 2013.


Allison will receive his award at a ceremony in London on Dec. 3.



###


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The Economist honors cancer immunotherapy pioneer James Allison


[ Back to EurekAlert! ]

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7-Nov-2013



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Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center



2013 Innovation Award for bioscience goes to MD Anderson scientist



HOUSTON For basic science research that opened a completely new approach for treating cancer, The Economist has named James Allison, Ph.D., professor and chair of Immunology at The University of Texas MD Anderson Cancer Center, as its 2013 Innovations Award winner in Bioscience.


Allison identified an immune checkpoint molecule that turns off T cells white blood cells that are the attack dogs of the immune system before they can mount a successful response to tumors that they are primed to destroy.


An antibody that blocks that immune checkpoint molecule, unleashing a T cell attack, became the first drug to ever extend survival for patients with late-stage melanoma. The U.S. Food and Drug Administration approved ipilumumab (Yervoy) for treatment of metastatic melanoma in 2011.


"The approval of ipilimumab in 2011 represents the culmination of years of research by Dr Allison into tumor immunotherapy," said Tom Standage, Digital Editor at The Economist and chairman of the panel of 30 judges. "We are delighted to recognize his pioneering achievement in the fight against cancer."


The Economist is a 170-year-old weekly news publication based in London with a circulation of 4.5 million worldwide. Its Innovation Awards recognize significant contributions in eight fields: Bioscience, Computing and Telecommunications, Consumer Products, Energy and Environment, Process and Services, Social and Economic, No Boundaries and Corporate.


"I'm honored to receive this award, which recognizes the increasing importance of immune therapy in the treatment of cancer due to the efforts of many scientists, clinicians and patients willing to participate in clinical trials," Allison said.


The adaptive immune system routinely identifies, destroys and remembers infections and abnormal cells. Yet cancer cells evade or suppress immune attack, largely frustrating efforts to develop vaccines and other immune therapies against tumors.


Drug treats immune system, not specific tumor


"Immune checkpoint blockade treats the immune system, not the tumor, so we expect this approach to work across many types of cancer," Allison said. In addition to melanoma, ipilumumab has been effective in clinical trials against prostate, kidney, lung and ovarian cancers.


Allison's basic science research on T cell biology uncovered the receptor on these cells used to recognize and bind to antigens abnormalities that mark defective cells or viruses and bacteria for attack.


He also found that T cells require a second molecular signal to launch a response after they've bound to an antigen. And he identified a molecule called CTLA-4 that acts as an off switch to inhibit activated T cells from attacking.


This led to development of ipilumumab to block CTLA-4. In clinical trials against stage 4 melanoma, the drug extinguished the disease in 20 percent of patients for up to 12 years and counting.


Since arriving at MD Anderson in November 2012, Allison founded and directs an immunotherapy platform to cultivate, support and test new development of immunology-based drugs and combinations. MD Anderson's Moon Shots program, designed to accelerate the conversion of scientific discoveries into clinical advances that reduce cancer deaths, taps the expertise of the immunotherapy platform.


Allison earned his doctorate from The University of Texas at Austin in 1978, joining MD Anderson's faculty after his postdoctoral fellowship. He left MD Anderson for the University of California, Berkeley and later moved to Memorial Sloan-Kettering Cancer Center in New York.


He is a member of the National Academy of Sciences, the Institute of Medicine of the National Academies and has won many honors for biomedical research, including the first AACR-CRI Lloyd J. Old Award in Cancer Immunology at the annual meeting of the American Association for Cancer Research in April 2013.


Allison will receive his award at a ceremony in London on Dec. 3.



###


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Source: http://www.eurekalert.org/pub_releases/2013-11/uotm-teh110713.php
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CIA reportedly pays to collect foreign call data from AT&T

The NSA wields its legal authority to collect phone call data from American telecom providers, but the CIA apparently doesn't even need to apply pressure. The New York Times claims that the agency has a years-old voluntary agreement with AT&T that lets it obtain the call records of foreign suspects; ...


Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/qGKQMY-DBiY/
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